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Category | P |
---|---|
Domain name | pgrn.ca |
IP | 204.209.20.31 |
Country by IP | CA |
Web server type | Apache |
Hostname | ws1.techweavers.net |
Problem gamblers come from all segments of the population, live in all regions of the province and include men and women of all ages and all socio-economic backgrounds. In addition to gambling for entertainment or fun, people with gambling problems will often gamble alone, chase losses and gamble to escape from problems. Visit website
The Problem Gambling Resources Network (PGRN) is a leader in providing problem gambling awareness, education, prevention, advocacy and treatment referrals within the Edmonton region. The PGRN offers 1 to 2 hour presentations aimed at promoting awareness about how gambling can impact the community & individuals. Visit website
The Problem Gambling Resources Network (PGRN) is a leader in providing problem gambling awareness, education, prevention, advocacy and treatment referrals within the Edmonton region. The PGRN offers 1 to 2 hour presentations aimed at promoting awareness about how gambling can impact the community & individuals. Visit website
The majority of the regional offices of Alberta Health Services offer programs to assist problem gamblers.For more information and to find an addiction services office near you, please call their 24-hour Help Line at 1-866-332-2322.; Northern Addictions Centre Grande Prairie Ablerta offers two services to individuals who are experiencing significat negative impacts in their lives … Visit website
The mission of the Pharmacogenomics Global Research Network is to catalyze and lead research in precision medicine for the discovery and translation of genomic variation influencing therapeutic and adverse drug effects. To accomplish this, We will: Promote research and implementation in pharmacogenomics; Provide a forum for collaboration ... Visit website
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and aging. ... 2 Alector, Inc., South San Francisco, CA 94080, USA. Electronic address: ar@alector.com ... Visit website
A new PGRN, PGRN IV, established July 1, 2015, represents a continuation of these research activities, however in a new model. This new model invites participation of all investigators with an interest in pharmacogenomics research to be part of the new network. Visit website
The Pharmacogenomics Research Network (PGRN), which is coordinated by the PGRN-Hub (see pgrn.org), has adopted a new approach to sponsor activities and develop shared resources to enhance research in pharmacogenomics. The PGRN is community-driven and is open to all scientists, where participating researchers’ needs drive its activities. Visit website
Background: Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are increasingly thought to contribute to FTLD-TDP-Pgrn disease … Visit website
Communications Committee. Mission Statement: To increase the visibility and growth of the PGRN in the scientific and medical communities, through social media and media sharing networks, blogs, pgrn.org and other potential networking opportunities. Chair: Sook Wah Yee. Co-Chair: Mohamed Shahin. Members: Meghan Arwood. Visit website
Affiliations 1 Denali Therapeutics, South San Francisco, CA, USA.; 2 Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators.; 3 On behalf of the ALLFTD investigators; Department of Neurology, College of Medicine, Mayo Clinic, … Visit website
Progranulin (PGRN) is a secreted growth factor important for neuronal survival and may do so, in part, by regulating lysosome homeostasis. ... CA). iPSC-neurons were fixed with 4 % paraformaldehyde for 15 min. Cells were then permeabilized with ice-cold methanol or 0.1 % triton X-100 in PBS for 10 min. After blocking with 0.1 % BSA or 5 % ... Visit website
CA-2712276-A1 chemical patent summary. Visit website
Global Public Relations Firms - PRGN world’s local public relations agency provides customized communication solutions that combine the scale and stature of an international PR firm with the deep insights and hands-on, senior-level service of a local agency. Check out the top Global Public Relations Firms & Influencer Marketing Agencies. Visit website
The parameters of micro CT, including BV/TV, Tb.Th and Tb.N, were analyzed, and results indicated that deficiency of PGRN significantly suppressed new bone formation induced by BMP-2, while recombinant PGRN can partially restore the new bone quality in PGRN−/− mice (n=6, p<0.05) (Fig. 5C, 5D and 5E). In addition, the samples from each group ... Visit website
Pro-CTSD, PSAP, and PGRN Network (PPPN) Proteins Interact with and Help Activate Each Other within the Lysosome. (A) Interaction between Prosaposin (PSAP) and Progranulin (PGRN) amplifies their response. Left: in the nonstressed state PSAP is transported to the endosome/lysosome via mannose-6-phosphate receptor (M6PR) and secreted PGRN is ... Visit website
Here we report that PGRN haploinsufficiency activates the extracellular signal-regulated protein kinases 1 and 2 pathway in a Ca(2+), protein kinase C-dependent, and pertussis toxin-sensitive manner. Addition of exogenous PGRN or conditioned medium from control cells normalized the response of PGRN-deficient lymphoblasts to serum activation. Visit website
PGRN levels were not significantly increased in patients with early-stage or late-stage EOC as a whole, but an increase in PGRN levels was associated with decreased overall survival in advanced EOC. Conclusions: SLPI levels are elevated in EOC, and SLPI shows promise as a diagnostic biomarker for patients with both elevated and normal CA-125 ... Visit website
Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN. In this study, we investigated the role of progranulin (PGRN), a secreted glycopro … Visit website
info@pgrn.ca Fees Fee: No Fee Reduction: No Membership Fee: Yes, Contact for details. Accessibility Wheelchair access: Yes - Second floor is not wheelchair accessible.Other disabled access: No - Legal Status Registered Not-For-Profit Topic(s) Mental Health / Addictions - Addiction Support Groups; Visit website
Mutations in the progranulin (PGRN) gene cause a tau pathology-negative and TDP43 pathology-positive form of frontotemporal lobar degeneration (FTLD-TDP).We generated a knock-in mouse harboring the R504X mutation (PGRN-KI). Phosphoproteomic analysis of this model revealed activation of signaling pathways connecting PKC and MAPK to tau prior to … Visit website
The PGRN offers 1 to 2 hour presentations aimed at promoting awareness about how gambling can impact the community & individuals. "Adolescent Gambling and Problem Gambling in Alberta" addresses gambling among young people while the "Community & Workplace Presentation" discusses problem gambling as an addiction and targets adults in the workplace, treatment … Visit website