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Category | O |
---|---|
Domain name | oxdj.uk |
IP | 85.233.160.22 |
Country by IP | GB |
Country by HTML code | GB |
Web server type | Apache |
Hostname | fwd0.hosts.co.uk |
Emails | tom@crossfade.co.uk |
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Anti-oxDJ-1 Antibody (Cys106), clone M149 clone M149, from mouse; Synonyms: Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, oxDJ-1 (Cys106); find Sigma-Aldrich-MABN1773 MSDS, related peer-reviewed papers, technical documents, … Visit website
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Using specific monoclonal antibodies against Cys106 oxidized DJ-1 (oxDJ-1), we examined oxDJ-1 immunoreactivity in brain sections from DJ-1 knockout and wild-type mice and in human brain sections from cases classified into different Lewy body stages of Parkinson disease and Parkinson disease with dementia. Oxidized DJ-1 immunoreactivity was ... Visit website
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Anti-oxDJ-1 Antibody (Cys106), clone M149 clone M149, from mouse; Synonyms: Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, oxDJ-1 (Cys106); find Sigma-Aldrich-MABN1773 MSDS, related peer-reviewed papers, technical documents, … Visit website
Dynamic polymerization of oxDJ-1 with a ring and a stacked structure was observed by an atomic force microscope. Collectively, these results clearly demonstrated the characteristic polymer formation of oxDJ-1 with a disulfide bond and noncovalent and covalent binding other than disulfide, which might be related to the biologic function of oxDJ-1. Visit website
OxDJ-1 levels in the brain, heart, and skeletal muscle were high compared with other tissues. In the brain, oxDJ-1 was detected in PD-related brain sites such as the substantia nigra (SN) of the ... Visit website
Glutathionylation of oxDJ-1 at 60 kDa band was completed during 1 h and was detected stably to 6 h at 37 °C (Supporting Information Figure S2). Glutathionylated oxDJ-1 was observed around the dimer form of oxDJ-1 in gel chromatography analysis (Figure Figure2 2 E). Taken together, these results suggest that oxDJ-1 is depolymerized via the ... Visit website
Therefore, oxDJ-1 IR may, at least in part, be hypothesized to reflect DJ-1 functions, via oxidation of Cys106, that detect and manage ROS-induced insults. Obvious oxDJ-1 and DJ-1 IR was observed in neuropil in multiple sites of human and mouse brains. A previous study has reported the presence of DJ-1 IR in neuropil . Visit website
OxDJ-1 levels in the brain, heart, and skeletal muscle were high compared with other tissues. In the brain, oxDJ-1 was detected in PD-related brain sites such as the substantia nigra (SN) of the midbrain, olfactory bulb (OB), and striatum. In aged wild-type mice, oxDJ-1 levels in the OB, striatum, and heart tended to decrease, while those in ... Visit website
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Glutathionylation of oxDJ-1 at 60 kDa band was completed during 1 h and was detected stably to 6 h at 37 °C (Supporting Information Figure S2). Glutathionylated oxDJ-1 was observed around the dimer form of oxDJ-1 in gel chromatography analysis (Figure Figure2 2 E). Taken together, these results suggest that oxDJ-1 is depolymerized via the ... Visit website
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