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Category | 3 |
---|---|
Domain name | 3w2q.us |
IP | 198.252.107.99 |
Country by IP | US |
RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198. Visit website
RCSB PDB is funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198. Visit website
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The L858R mutation enhances clinical sensitivity to gefitinib and erlotinib as compared with wild type and reduces the relative sensitivity to lapatinib. In contrast, the T790M mutation confers drug resistance to gefitinib and erlotinib. We determined crystal structures of the wild-type and T790M/L858R double mutant EGFR kinases with reversible ... Visit website
HKI is a Ligand Of Interest in 3W2Q designated by the RCSB. Help . Best-fitted instance in this entry: Other instances in this entry: ... (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute … Visit website
Version Number Version Date Version Type/Reason Version Change Revised CIF Category; 1.0: 2013-01-16: Initial release: 1.1: 2013-08-21: Database references: 1.2 Visit website
1 PTKc_EGFR. cd05108 (13-325): Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor. PKc_like superfamily. cl21453 (13-325): The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. Visit website
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LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Visit website
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3W2Q EGFR (Epidermal growth factor receptor) Group: TYR Uniprot: EGFR_HUMAN Organism: Homo sapiens Domain boundary: 712 - 970 Resolution: 2.2. Chain id Spatial Dihedral C-helix Ligand Type Residues in structure Unresolved residues in A-loop; A: DFGin: BLAminus: out: HKI: Type1.5_Front: 698 - 1017: 0: Visit website
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PDB Entry - 3W2Q (Status - Released) Summary information: Title: EGFR kinase domain T790M/L858R mutant with HKI-272 DOI: 10.2210/pdb3w2q/pdb Primary publication DOI: 10.1021/ml300327z Entry authors: Sogabe, S., Kawakita, Y., Igaki, S. Initial deposition on: 3 December 2012 Initial release on: 16 January 2013 Latest revision on: 25 December 2019 … Visit website
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